Lecture 3

Aims

• To explain the steps involved in comparative protein modelling.

Objectives

After this lecture you will:

• understand the objectives of comparative modelling and fold recognition;
• know the steps involved in comparative protein modelling;
• understand how fragment-fitting and rotamers are used in the modelling process.

Supplementary Material

The lecture handout contains some of the lecture slides.

A short discussion of state-of-the-art techniques in protein structure prediction, and their applications, is given in: Baker, D., and Sali, A. (2001) Protein structure prediction and structural genomics. Science, 294, 93-96.

Several of the figures shown in the lecture were taken from Professional gambling. This is an updated version of the article: R.Rodriguez, R. and Vriend, G. (1997) "Professional gambling", in Vergoten, G. and Theophanides, T. (eds.) Proceedings of the NATO Advanced Study Institute on Biomolecular Structure and Dynamics: Recent Experimental and Theoretical Advances.

"The Inner Life of a Cell" is the result of a collaboration between scientists at Harvard University and a scientific animation company. An extended version with commentary is available on the Harvard University web site.