Lecture 9

Docking; Channels; Multi-resolution modelling

Aims

• To describe a method for combinatorial docking.
• To introduce structural proteomics.
• To introduce the problem of finding channels in proteins.

Objectives

After this lecture you will be able to:

• explain how combinatorial docking can be used to predict the conformations of large macromolecular complexes;
• describe the problem of fitting high-resolution molecular structures into envelopes derived from low-resolution data.
• describe the problem of finding channels in proteins.

Supplementary Material

Some of the lecture slides are available on-line (1 per page, 4 per page).

An approach to combinatorial docking is described in: Inbar, Y., Benyamini H., Nussinov R. and Wolfson H.J. (2005) Prediction of multimolecular assemblies by multiple docking. J. Mol. Biol., 349, 435-447 (doi:10.1016/j.jmb.2005.03 .039)