After this lecture you will:
Some of the lecture slides are available on-line (PDF).
The computational approach used to design Top7 is described in:
Kuhlman, B., Dantas, G., Ireton, G.C., Varani, G., Stoddard, B.L. and Baker, D. (2003) Design of a novel globular protein fold with atomic-level accuracy. Science, 302, 1364-1368 (doi:10.1126/science.1089427)
Some creative ways of combining antibody domains to form novel engineered proteins are shown on Nico Mertens' web site.