Lecture GK-12

New fold methods for protein modelling

Aims

• To introduce the ab initio protein folding problem.
• To give an overview of the protein structure prediction method of Simons et al. (1997).
• To introduce lattice models.

Objectives

After this lecture you will:

• be aware of the the ab initio protein folding problem;
• understand in outline the protein structure prediction algorithm of Simons et al. (1997);
• be aware of how lattice models can facilitate experimentation with, and evaluation of, algorithmic approaches to protein folding.

Supplementary Material

Some of the lecture slides are available on-line (PDF).

The ab initio protein structure prediction algorithm introduced in this lecture is described in:

Simons, K.T., Kooperberg, C., Huang, E. and Baker, D. (1997) Assembly of Protein Tertiary Structures from Fragments with Similar Local Sequences using Simulated Annealing and Bayesian Scoring Functions. J. Mol. Biol., 268, 209-225 (PubMed)