Bioinformatics (2011/2012)

Lecture GK-5

Sequence alignment



After this lecture you will be able to:

Supplementary Material

The lecture handout, featuring some of the lecture slides, is available on-line.
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Tutorial on The Statistics of Sequence Similarity Scores by Stephen Altschul, author of BLAST.

The method for deriving BLOSUM matrices is described in: Henikoff, S. and Henikoff, J.G. (1992) Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci USA, 89, 10915-10919 (PubMed).

There is an overview of BLAST and substitution matrices in: Pertsemlidis, A. and Fondon, J.W. (2001) Having a BLAST with bioinformatics (and avoiding BLASTphemy), Genome Biol., 2, reviews2002.1-reviews2002.10.

Last Modified: 6 February 2012 by Graham Kemp