Peter Gennemark (PhD)

Senior research scientist (DMPK, Modelling and simulation), AstraZeneca, Mölndal, Sweden

Before March 2011, at Mathematical sciences, University of Göteborg, and Department of mathematics, Uppsala University.

Research interests

Refereed publications

Sundqvist et al. Quantifying and communicating uncertainty in human dose-prediction. CPT:Pharmacometrics and systems pharmacology 2015 Apr 16 [first published online].

Buchanan et al. Structural and functional characterisation of a specific antidote for ticagrelor. Blood 2015 Mar 18 [Epub ahead of print].

Davidsson et al. Studies of nontarget-mediated distribution of human full-length IgG1 antibody and its FAb fragment in cardiovascular and metabolic-related tissues. J Pharm Sci 104(5):1825-31, 2015.

Gennemark P, Hjorth S, Gabrielsson J. Modeling energy intake by adding homeostatic feedback and drug intervention. J Pharmacokinetics and pharmacodynamcis 42(1):79-96, 2015.

Lindhardt E, Gennemark P. Automated analysis of routinely generated preclinical pharmacokinetic and pharacodynamic data. J Bioinform Comput Biol 12(3): 1450010, 2014 (submitted pdf)

Gennemark P, et al. A modeling approach for compounds affecting body composition J Pharmacokinetics and pharmacodynamcis 40(6):651-67, 2013. doi: 10.1007/s10928-013-9337-x (submitted pdf, submitted supplement)

Gennemark P, Wedelin D.ODEion - a software module for structural identification of ordinary differential equations J Bioinform Comput Biol 12(1):1350015, 2014. (submitted pdf)

Johansson CC, Gennemark P, Artursson P, Abelö A, Ashton M, Jansson-Löfmark R. Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat. J Pharmacokinet Pharmacodyn. 40(1):117-28, 2013. doi: 10.1007/s10928-012-9293-x

Kühn, C., Gennemark, P. Modeling yeast osmoadaptation at different levels of resolution J Bioinform Comput Biol 11(2):1330001, 2013 doi: 10.1142/S0219720013300013

Gennemark P., Danis A., Nyberg J., Hooker A., Tucker W. Optimal design in population kinetic experiments by set-valued methods. Gennemark P, Danis A, Nyberg J, Hooker AC, Tucker W. Optimal Design in Population Kinetic Experiments by Set-Valued Methods. AAPS J. 13(4) 495-507. 2011.

Jörnsten R., Abenius T., Kling T., Schmidt L., Johansson E., Nordling T., Nordlander B., Sander C., Gennemark P., Funa K., Nilsson B., Lindahl L., Nelander S. Network modeling of the transcriptional effects of copy number aberrations in glioblastoma. 2011. Molecular Systems Biology 7:486.

Kattas, GD, Gennemark, P. and Wedelin, D. 2010. Structural identification of GMA models: algorithm and model comparison. Proceedings of the 8th International Conference on Computational Methods in Systems Biology, ACM New York, NY, USA 2010, ISBN: 978-1-4503-0068-1.

Kühn C., Prasad K.V.S., Klipp E., Gennemark P. 2010. Formal representation of the High Osmolarity Glycerol pathway. Genome informatics 22:69-83

Gennemark, P. and Wedelin, D. 2009. Improved Parameter Estimation for Completely Observed Ordinary Differential Equations with Application to Biological Systems. In Computational methods in systems biology, LNCS 5688, 205-217. ISBN 978-3-642-03844-0.

Gennemark P. and Wedelin D. 2009. D. Benchmarks for identification of ordinary differential equations from time series data. Bioinformatics 25(6):780-6.

Nelander S., Wang W., Nilsson B., She Q-B., Pratilas C., Rosen N., Gennemark P. and Sander C. 2008. Models from experiments: combinatorial drug perturbations of cancer cells, Molecular Systems Biology 4:216.

Wedelin, D. and Gennemark, P. 2008. On the design and evaluation of identification algorithms for ordinary differential equations. 5th Workshop on Computation of Biochemical Pathways and Genetic Networks. BIOQUANT, Heidelberg, p. 35-41. ISBN/ISSN: 978-3-8325-1993-3

Gennemark, P. and Wedelin, D. 2007. Efficient algorithms for ordinary differential equation model identification of biological systems. IET Systems Biology, 1 (2) pp. 120-129. (submitted pdf, submitted supplement)

Gennemark P., Nordlander B., Hohmann S. and Wedelin D. 2006. A simple mathematical model of adaptation to high osmolarity in yeast. In Silico Biology 6, 0018 (pdf).

Gennemark P. 2005. PhD thesis; Modeling and identification of biological systems with emphasis on osmoregulation in yeast, ISBN 91-7291-647-8.

Klipp E, Nordlander B, Kruger R, Gennemark P, Hohmann S. 2005. Integrative model of the response of yeast to osmotic shock. Nature Biotechnology. 23(8):975-82.

Other publications

Gennemark P. 2013. Incorporating model structure unceratinty in model-based drug discovery. Abstracts of the Annual Meeting of the Population Approach Group in Europe 22:2743. ISSN 1871-6032.

Aoki Y, Sundqvist M, Whatling C, Ronnborg A, Gennemark P, Hooker AC.. 2013. PopED lite an easy to use experimental design software for preclinical studies. Abstracts of the Annual Meeting of the Population Approach Group in Europe 22:2740. ISSN 1871-6032.

Gennemark P. 2012. Experimental design based on meachanistic mathematical modeling of body composition and energy turnover. Abstracts of the Annual Meeting of the Population Approach Group in Europe 21:2370. ISSN 1871-6032.

Gennemark P., Danis A., Nyberg J., Hooker A.C., Tucker W. 2011. Optimal design in population kinetic experiments by set-valued methods. Abstracts of the Annual Meeting of the Population Approach Group in Europe 20:2244. ISSN 1871-6032.

Gennemark P. 2010. Lärande i interdisciplinära miljöer.

Nordlander B., Gennemark P., Tamas M., Wedelin D., Hohmann S. Downregulation of the HOG MAP kinase pathway during yeast osmoadaptation. Yeast. 20 (2003).

Gennemark P. 2002. A model identification algorithm for cell signalling pathways. Licentiate thesis.

Gennemark P. Nyman M. 2000. Interactions between [poly(R)-3-hydroxybutyrate] (PHB) and in vitro cultured macrophages and fibroblasts. Master thesis.